ReadyPlanet.com
Anti-inflammatory article

Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol).

Halpern GM.

University of California, USA.
A lipid-rich extract, prepared by supercritical fluid (CO2) extraction of freeze-dried stabilized NZ green-lipped mussel powder (Lyprinol) has shown significant anti-inflammatory (AI) activity when given to animals and humans. When treated p.o. with Lyprinol, Wistar and Dark Agouti rats developed neither adjuvant-induced polyarthritis or collagen(II)-induced auto-allergic arthritis. This was achieved with doses < NSAIDs, and 200 times < of other seed or fish oils. Lyprinol subfractions inhibited LTB4 biosynthesis by PMN in vitro, and PGE2 production by activated macrophages. Much of this AI activity was associated with omega-3 PUFAs and natural antioxidants [e.g. carotenoids]. In contrast to NSAIDs, Lyprinol is non-gastro toxic in disease-stressed rats at 300 mg/kg p.o., and does not affect platelet aggregation [human, rat]. Clinical studies, either controlled or randomized, have demonstrated very significant AI activity in patients with osteoarthritis (OA), rheumatoid arthritis (RA), asthma, and other inflammatory conditions. Lyprinol is a reproducible, stable source of bioactive lipids with much greater potency than plant/marine oils currently used as nutritional supplements to ameliorate signs of inflammation.


Publication Types:

  • Review
  • Review, Tutorial


PMID: 11094640 [PubMed - indexed for MEDLINE]

 




Sub GLM

Clinical efficacy and safety of Lyprinol article
Influence of green lipped mussels article
Efficacy and tolerability article



powered by SalesDesk
Chat: Line/Facebook
แบบฟอร์ม
แชทผ่าน LINE
แชทผ่าน Facebook
สอบถามเกี่ยวกับโปรโมชั่น
กำลังบันทึกข้อมูล...
ขอบคุณสำหรับข้อมูลของท่าน เราจะติดต่อกลับอย่างเร็วที่สุด
สอบถามเกี่ยวกับโปรโมชั่น
กรุณากรอกข้อมูลเพื่อให้เราติดต่อกลับ
แชทผ่าน LINE
สแกน QR Code เพื่อแชทกับเรา