Effects of a combined micronutrient article

Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women.

Hininger I, Favier M, Arnaud J, Faure H, Thoulon JM, Hariveau E, Favier A, Roussel AM.

1LBSO, Faculte de Pharmacie, Universite Joseph. Fourier, La Tronche, France.

OBJECTIVE:: To investigate the possible beneficial effects of a micronutrient supplementation to apparently healthy pregnant women on maternal biological status and new born anthropometric characteristics. SETTING:: Departments of Obstetric of the University Hospital of Grenoble (France) and Lyon (France), Laboratoire of Biology of Oxidative Stress, UFR de Pharmacie. Grenoble (France). STUDY DESIGN:: Double-blind, randomized placebo-controlled intervention trial. SUBJECTS:: A total of 100 apparently healthy pregnant women were recruited at 14+/-2 weeks of gestation to delivery. At the end, they were 65 women to follow out the study. INTERVENTIONS:: Daily consumption over gestation of a miconutrients supplement or placebo. MAIN OUTCOME MEASURES:: Plasma micronutrient levels and oxidative stress parameters were measured in mothers at 14 and 38 weeks of gestation. New born's anthropometric characteristics were measured at delivery. RESULTS:: In the supplemented group, folic acid, vitamin C, E, B(2), B(6) and beta-carotene levels were higher than in the placebo group. Oxidative stress parameters were not different between the groups. Birth weights were increased by 10% and the number of low newborn weights (<2700g) decreased significantly when the mother received the supplementation. Maternal plasma Zn levels were positively correlated to the newborn heights. CONCLUSION:: A regular intake of a micronutrient supplement at nutritional dose may be sufficient to improve micronutrient status of apparently healthy pregnant women and could prevent low birth weight of newborn. SPONSORSHIP:: The supplement and placebo were supplied and the study was partially funded by BOIRON Pharmaceutical Company. European Journal of Clinical Nutrition (2004) 58, 52-59. doi:10.1038/sj.ejcn.1601745

PMID: 14679367 [PubMed - in process]


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